Mouse Siglec1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Siglec1
Locus ID	20612
Kit Components	GA203997G1, Siglec1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA203997G2, Siglec1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA203997G3, Siglec1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_011426
Synonyms	Cd169; Siglec-1; Sn
Summary	Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells (By similarity). Preferentially binds to alpha-2,3-linked sialic acid. Binds to SPN/CD43 on T-cells. May play a role in hematopoiesis. May act as a counter-receptor for CLEC10A in lymph node.[UniProtKB/Swiss-Prot Function]

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