Mouse Srebf2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Srebf2
Locus ID	20788
Kit Components	GA204104G1, Srebf2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA204104G2, Srebf2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA204104G3, Srebf2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_033218
Synonyms	AI608257; bHLHd2; lop13; nuc; SREBP-2; SREBP2; SREBP2gc
Summary	Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway. Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes.[UniProtKB/Swiss-Prot Function]

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