Mouse Tfap2a activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Tfap2a
Locus ID	21418
Kit Components	GA204244G1, Tfap2a gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA204244G2, Tfap2a gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA204244G3, Tfap2a gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001122948, NM_001301674, NM_011547
Synonyms	AP-2; Ap-2 (a); Ap2; AP2alpha; Ap2tf; Tcfap2a
Summary	This gene is a member of the activator protein 2 (AP-2) transcription factor family. The protein encoded by this gene can act as both an activator and repressor of gene transcription, and plays an important role in early embryogenesis, specifically in cranial development. This protein forms both homodimers and heterodimers, and binds to a GC-rich consensus sequence found in some promoters and enhancers. Disruption of this gene causes perinatal death, with neural tube, craniofacial, and limb mesenchyme defects. Alternative splicing results in multiple transcript variants that encode multiple protein isoforms. [provided by RefSeq, Sep 2014]

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