Mouse Thbd activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Thbd
Locus ID	21824
Kit Components	GA204333G1, Thbd gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA204333G2, Thbd gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA204333G3, Thbd gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_009378
Synonyms	AI385582; CD141; TM
Summary	Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.[UniProtKB/Swiss-Prot Function]

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