Mouse Ubr1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Ubr1
Locus ID	22222
Kit Components	GA204525G1, Ubr1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA204525G2, Ubr1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA204525G3, Ubr1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_009461
Synonyms	AI504731
Summary	E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth (By similarity).[UniProtKB/Swiss-Prot Function]

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