Mouse Wbp2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Wbp2
Locus ID	22378
Kit Components	GA204619G1, Wbp2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA204619G2, Wbp2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA204619G3, Wbp2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001347642, NM_016852, NM_001361446
Summary	Acts as transcriptional coactivator of estrogen and progesterone receptors (ESR1 and PGR) upon hormone activation. In presence of estrogen, binds to ESR1-responsive promoters. Required for YAP1 coactivation function on PGR activity. Synergizes with WBP2 in enhancing PGR activity (By similarity). Modulates expression of post-synaptic scaffolding proteins via regulation of ESR1, ESR2 and PGR (PubMed:26881968).[UniProtKB/Swiss-Prot Function]

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