Mouse Wnt3a activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Wnt3a
Locus ID	22416
Kit Components	GA204638G1, Wnt3a gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA204638G2, Wnt3a gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA204638G3, Wnt3a gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_009522
Synonyms	vt; Wnt-3a
Summary	Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:26902720). Required for normal embryonic mesoderm development and formation of caudal somites (PubMed:8299937). Required for normal morphogenesis of the developing neural tube (PubMed:8299937). Mediates self-renewal of the stem cells at the bottom on intestinal crypts (in vitro) (PubMed:26902720).[UniProtKB/Swiss-Prot Function]

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