Mouse Zfp57 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Zfp57
Locus ID	22715
Kit Components	GA204714G1, Zfp57 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA204714G2, Zfp57 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA204714G3, Zfp57 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001013745, NM_001168501, NM_001168502, NM_009559, NR_033137
Synonyms	G19; Zfp-57
Summary	Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions. Required for the establishment of maternal methylation imprints at SNRPN locus. Acts as a transcriptional repressor in Schwann cells. Binds to a 5'-TGCCGC-3' consensus sequence and recognizes the methylated CpG within this element.[UniProtKB/Swiss-Prot Function]

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