Mouse Adamts5 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Adamts5
Locus ID	23794
Kit Components	GA204757G1, Adamts5 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA204757G2, Adamts5 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA204757G3, Adamts5 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_011782
Synonyms	9530092O11Rik; ADAM-TS5; ADAMTS1; ADAMTS11; ADMP-2; AI481094; ASMP-2
Summary	This gene encodes a member of "a disintegrin and metalloproteinase with thrombospondin motifs" (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. The encoded preproprotein undergoes proteolytic processing to generate an active, zinc-dependent aggrecanase enzyme. Mice lacking the encoded protein are protected from surgery-induced osteoarthritis and antigen-induced arthritis. [provided by RefSeq, May 2016]

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