Mouse Hax1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Hax1
Locus ID	23897
Kit Components	GA204806G1, Hax1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA204806G2, Hax1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA204806G3, Hax1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001282032, NM_001310681, NM_011826
Synonyms	HAX-1; Hs1bp1; HSP1BP-1; mHAX-1s; SIG-111; Silg111
Summary	Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools.[UniProtKB/Swiss-Prot Function]

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