Mouse Sh2b2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Sh2b2
Locus ID	23921
Kit Components	GA204813G1, Sh2b2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA204813G2, Sh2b2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA204813G3, Sh2b2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001302938, NM_001302939, NM_018825
Synonyms	Aps
Summary	Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3 (By similarity).[UniProtKB/Swiss-Prot Function]

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