Mouse Dnajb6 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Dnajb6
Locus ID	23950
Kit Components	GA204827G1, Dnajb6 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA204827G2, Dnajb6 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA204827G3, Dnajb6 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001037940, NM_001037941, NM_001127367, NM_011847, NM_001359198, NR_152863
Synonyms	mDj4; Mrj
Summary	Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins (By similarity). Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity (By similarity).[UniProtKB/Swiss-Prot Function]

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