Mouse Mapk10 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Mapk10
Locus ID	26414
Kit Components	GA204958G1, Mapk10 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA204958G2, Mapk10 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA204958G3, Mapk10 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001081567, NM_009158
Synonyms	C230008H04Rik; JNK3; JNK3B1; JNK3B2; p54bSAPK; p493F12; SAPK(beta); Serk2
Summary	The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]

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