Mouse Spo11 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Spo11
Locus ID	26972
Kit Components	GA205064G1, Spo11 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA205064G2, Spo11 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA205064G3, Spo11 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001083959, NM_001083960, NM_001305434, NM_012046
Synonyms	AI449549; Spo11a; Spo11b
Summary	Isoform 1: Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with TOP6BL, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination (PubMed:26917764). The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles. Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2 (PubMed:22346761).[UniProtKB/Swiss-Prot Function]

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