Mouse Polk activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Polk
Locus ID	27015
Kit Components	GA205069G1, Polk gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA205069G2, Polk gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA205069G3, Polk gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001347602, NM_001347603, NM_001347604, NM_001347606, NM_012048, NR_144622, NR_144623, NR_144624, NR_144625
Synonyms	Dinb1; DINP
Summary	DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls (PubMed:12432099). Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity (By similarity).[UniProtKB/Swiss-Prot Function]

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