Mouse Polr2m activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Polr2m
Locus ID	28015
Kit Components	GA205194G1, Polr2m gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA205194G2, Polr2m gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA205194G3, Polr2m gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001164793, NM_178602
Synonyms	AA407243; AA408799; AI303746; AW553238; D9Wsu138e; Grinl1a; mKIAA4185
Summary	Isoform 1 appears to be stable component of the Pol II(G) complex form of RNA polymerase II. Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. Isoform 1 may play a role in Mediator-dependent regulation of transcription activation. Isoform 1 acts in vitro as negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II (By similarity).[UniProtKB/Swiss-Prot Function]

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