Mouse Mga activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Mga
Locus ID	29808
Kit Components	GA205224G1, Mga gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA205224G2, Mga gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA205224G3, Mga gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001164274, NM_013720
Synonyms	AV312082; C80739; C130042M01Rik; D030062C11Rik; Mad5
Summary	Functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box family target genes. Functions as a repressor or an activator. Binds to 5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence and seems to regulate MYC-MAX target genes. Suppresses transcriptional activation by MYC and inhibits MYC-dependent cell transformation. Function activated by heterodimerization with MAX. This heterodimerization serves the dual function of both generating an E-box-binding heterodimer and simultaneously blocking interaction of a corepressor.[UniProtKB/Swiss-Prot Function]

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