Mouse Dlc1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Dlc1
Locus ID	50768
Kit Components	GA205350G1, Dlc1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA205350G2, Dlc1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA205350G3, Dlc1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001194940, NM_001194941, NM_015802
Synonyms	A730069N07Rik; Arhgap7; dlc-1; HP; STARD12
Summary	Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality (By similarity).[UniProtKB/Swiss-Prot Function]

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