Mouse Fbxl3 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Fbxl3
Locus ID	50789
Kit Components	GA205369G1, Fbxl3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA205369G2, Fbxl3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA205369G3, Fbxl3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001347600, NM_001347601, NM_015822, NM_001360341, NM_001360342
Synonyms	AU041772; AW212966; FBK; Fbl3a; Fbxl3a; Ovtm; Play68
Summary	Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2. Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex.[UniProtKB/Swiss-Prot Function]

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