Mouse Nckap1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Nckap1
Locus ID	50884
Kit Components	GA205389G1, Nckap1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA205389G2, Nckap1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA205389G3, Nckap1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001290745, NM_016965, NM_001355410, NM_001355411
Synonyms	C79304; H19; Hem-2; Hem2; mh19; mKIAA0587; Nap1; p125Nap1
Summary	Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (PubMed:27605705).[UniProtKB/Swiss-Prot Function]

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