Mouse Nus1 activation kit by CRISPRa
CAT#: GA205437
Nus1 CRISPRa kit - CRISPR gene activation of mouse NUS1 dehydrodolichyl diphosphate synthase subunit
CNY 12255.00
Specifications
Product Data | |
Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
Symbol | Nus1 |
Locus ID | 52014 |
Kit Components | GA205437G1, Nus1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA205437G2, Nus1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA205437G3, Nus1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
Reference Data | |
RefSeq | NM_030250 |
Synonyms | 1600027K07Rik; AU019165; AW538011; BC003223; D10Ertd438e |
Summary | With DHDDS, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol. Acts as a specific receptor for the N-terminus of Nogo-B, a neural and cardiovascular regulator.[UniProtKB/Swiss-Prot Function] |
Documents
Resources
基因表达相关资源 |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN511369 | Nus1 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. |
CNY 8680.00 |