Mouse Rassf5 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Rassf5
Locus ID	54354
Kit Components	GA205678G1, Rassf5 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA205678G2, Rassf5 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA205678G3, Rassf5 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001311094, NM_001313731, NM_018750
Synonyms	1300019G20Rik; Maxp1; Nore1; Nore1A; Nore1B; Rapl
Summary	Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing (By similarity). May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis.[UniProtKB/Swiss-Prot Function]

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