Mouse Otud5 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Otud5
Locus ID	54644
Kit Components	GA205749G1, Otud5 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA205749G2, Otud5 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA205749G3, Otud5 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001290536, NM_001290537, NM_138604
Synonyms	AA407879; AI553596; BB114028; DUBA; DXImx46e; Sfc7
Summary	Deubiquitinating enzyme that functions as negative regulator of the innate immune system. Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro) (By similarity).[UniProtKB/Swiss-Prot Function]

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