Mouse Hes6 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Hes6
Locus ID	55927
Kit Components	GA205772G1, Hes6 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA205772G2, Hes6 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA205772G3, Hes6 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_019479, NM_001360899, NM_001360900
Synonyms	AI326893; bHLHb41
Summary	Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation.[UniProtKB/Swiss-Prot Function]

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