Mouse Lgals8 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Lgals8
Locus ID	56048
Kit Components	GA205819G1, Lgals8 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA205819G2, Lgals8 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA205819G3, Lgals8 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001199043, NM_001291055, NM_001291057, NM_001291060, NM_018886
Synonyms	1200015E08Rik; AI326142; D13Ertd524e; Lgals-8
Summary	Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy. Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane; these ligands becoming exposed to the cytoplasm following rupture. Restricts infection by initiating autophagy via interaction with CALCOCO2/NDP52. Required to restrict infection of bacterial invasion such as S.typhimurium. Also required to restrict infection of Picornaviridae viruses. Has a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans.[UniProtKB/Swiss-Prot Function]

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