Mouse Apip activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Apip
Locus ID	56369
Kit Components	GA205929G1, Apip gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA205929G2, Apip gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA205929G3, Apip gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_019735, NM_001355473, NM_001355474
Synonyms	APIP2; CGI-29; Mmrp19
Summary	Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.[UniProtKB/Swiss-Prot Function]

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