Mouse Tmem59 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Tmem59
Locus ID	56374
Kit Components	GA205931G1, Tmem59 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA205931G2, Tmem59 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA205931G3, Tmem59 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_029565
Synonyms	1110001M20Rik; 3110046P06Rik; AI256529; D4Ertd20e; MTDCF1; ORF18
Summary	Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding.[UniProtKB/Swiss-Prot Function]

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