Mouse Ripk3 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Ripk3
Locus ID	56532
Kit Components	GA206024G1, Ripk3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA206024G2, Ripk3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA206024G3, Ripk3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001164107, NM_001164108, NM_019955
Synonyms	2610528K09Rik; AW107945; Rip3
Summary	Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.[UniProtKB/Swiss-Prot Function]

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