Mouse Clec4n activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Clec4n
Locus ID	56620
Kit Components	GA206039G1, Clec4n gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA206039G2, Clec4n gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA206039G3, Clec4n gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001190320, NM_001190321, NM_020001
Synonyms	Clec6a; Clecsf10; Nkcl
Summary	Binds high-mannose carbohydrates in a Ca(2+)-dependent manner. Functional receptor for alpha-mannans on C.albicans hypheas. Plays an important role in the host defense against C.albicans infection by inducing TH17 cell differentiation. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and Syk-CARD9-NF-kappa-B-dependent pathway.[UniProtKB/Swiss-Prot Function]

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