Mouse Zbp1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Zbp1
Locus ID	58203
Kit Components	GA206262G1, Zbp1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA206262G2, Zbp1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA206262G3, Zbp1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001139519, NM_021394
Synonyms	2010010H03Rik; Dai; Dlm1; mZaDLM
Summary	Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3.[UniProtKB/Swiss-Prot Function]

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