Mouse Arpp19 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Arpp19
Locus ID	59046
Kit Components	GA206355G1, Arpp19 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA206355G2, Arpp19 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA206355G3, Arpp19 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001142655, NM_021548, NM_001357878, NM_001357879, NM_001357880, NM_001357881, NR_152135
Synonyms	19kDa; 2700024H10Rik; ARPP-19; Arpp12; AW559096
Summary	Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression by binding to the NGF-regulatory region of its mRNA (By similarity).[UniProtKB/Swiss-Prot Function]

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