Mouse Ireb2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Ireb2
Locus ID	64602
Kit Components	GA206478G1, Ireb2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA206478G2, Ireb2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA206478G3, Ireb2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_022655
Synonyms	D9Ertd85e; Irp2
Summary	RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3' UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.[UniProtKB/Swiss-Prot Function]

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