Mouse Coprs activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Coprs
Locus ID	66423
Kit Components	GA206770G1, Coprs gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA206770G2, Coprs gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA206770G3, Coprs gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_025556, NM_001359059
Synonyms	1700029I03Rik; 2410022L05Rik; AA409325; AI256813; C85432; Copr5
Summary	Histone-binding protein required for histone H4 methyltransferase activity of PRMT5. Specifically required for histone H4 'Arg-3' methylation mediated by PRMT5, but not histone H3 'Arg-8' methylation, suggesting that it modulates the substrate specificity of PRMT5. Specifically interacts with the N-terminus of histone H4 but not with histone H3, suggesting that it acts by promoting the association between histone H4 and PRMT5. Involved in CCNE1 promoter repression (By similarity). Plays a role in muscle cell differentiation by modulating the recruitment of PRMT5 to the promoter of genes involved in the coordination between cell cycle exit and muscle differentiation.[UniProtKB/Swiss-Prot Function]

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