Mouse Yaf2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Yaf2
Locus ID	67057
Kit Components	GA207113G1, Yaf2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA207113G2, Yaf2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA207113G3, Yaf2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_024189, NR_028315
Synonyms	2810021M11Rik
Summary	Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent transcriptional activation. Increases calpain 2-mediated proteolysis of YY1 in vitro. Component of the E2F6.com-1 complex, a repressive complex that methylates 'Lys-9' of histone H3, suggesting that it is involved in chromatin-remodeling.[UniProtKB/Swiss-Prot Function]

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