Mouse Samd8 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Samd8
Locus ID	67630
Kit Components	GA207428G1, Samd8 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA207428G2, Samd8 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA207428G3, Samd8 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_026283, NM_001359953, NM_001359954
Synonyms	1110053F04Rik; 1700010P07Rik; SMSr
Summary	sphingomyelin synthases synthesize sphingolipids through transfer of a phosphatidyl head group on to the primary hydroxyl of ceramide. SAMD8 is an endoplasmic reticulum (ER) transferase that has no sphingomyelin synthase activity but can convert phosphatidylethanolamine (PE) and ceramide to ceramide phosphatidylethanolamine (CPE) albeit with low product yield. Appears to operate as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum rather than a converter of ceramides. Seems to be critical for the integrity of the early secretory pathway (By similarity).[UniProtKB/Swiss-Prot Function]

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