Mouse Kirrel3 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Kirrel3
Locus ID	67703
Kit Components	GA207463G1, Kirrel3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA207463G2, Kirrel3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA207463G3, Kirrel3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001190911, NM_001190912, NM_001190913, NM_001190914, NM_026324
Synonyms	1500010O20Rik; 2900036G11Rik; mKIAA1867; NEPH2; SST4
Summary	Synaptic adhesion molecule required for the formation of target-specific synapses (PubMed:23637329, PubMed:26575286). Required for formation of target-specific synapses at hippocampal mossy fiber synapses. Required for formation of mossy fiber filopodia, the synaptic structures connecting dentate granule and GABA neurons. Probably acts as a homophilic adhesion molecule that promotes trans-cellular interactions and stabilize mossy fiber filipodia contact and subsequent synapse formation (PubMed:26575286). Required for the coalescence of vomeronasal sensory neuron axons (PubMed:23637329). May be involved in the hematopoietic supportive capacity of stroma cells; the secreted extracellular domain is directly responsible for supporting hematopoietic stem cells (PubMed:12665856).[UniProtKB/Swiss-Prot Function]

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