Mouse Mpzl1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Mpzl1
Locus ID	68481
Kit Components	GA207826G1, Mpzl1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA207826G2, Mpzl1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA207826G3, Mpzl1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001001880, NM_001083897, NM_001347128
Synonyms	1110007A10Rik; PZR
Summary	Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. Isoform 2 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2, may be involved in regulation of integrin-mediated cell motility (By similarity).[UniProtKB/Swiss-Prot Function]

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