Mouse Stimate activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Stimate
Locus ID	69179
Kit Components	GA208080G1, Stimate gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA208080G2, Stimate gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA208080G3, Stimate gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_028839
Synonyms	1810038N08Rik; 2310014H19Rik; AW554125; STIMATE
Summary	Acts as a regulator of store-operated Ca(2+) entry (SOCE) at junctional sites that connect the endoplasmic reticulum (ER) and plasma membrane (PM), called ER-plasma membrane (ER-PM) junction or cortical ER. SOCE is a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts by interacting with STIM1, promoting STIM1 conformational switch. Involved in STIM1 relocalization to ER-PM junctions. Contributes to the maintenance and reorganization of store-dependent ER-PM junctions.[UniProtKB/Swiss-Prot Function]

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