Mouse Afg3l2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Afg3l2
Locus ID	69597
Kit Components	GA208241G1, Afg3l2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA208241G2, Afg3l2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA208241G3, Afg3l2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_027130
Synonyms	2310036I02Rik; AW260507; Emv66; par
Summary	ATP-dependent protease which is essential for axonal and neuron development (PubMed:18337413, PubMed:27642048). In neurons, mediates degradation of SMDT1/EMRE before its assembly with the uniporter complex, limiting the availability of SMDT1/EMRE for MCU assembly and promoting efficient assembly of gatekeeper subunits with MCU (By similarity). Required for the maturation of paraplegin (SPG7) after its cleavage by mitochondrial-processing peptidase (MPP), converting it into a proteolytically active mature form.[UniProtKB/Swiss-Prot Function]

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