Mouse Pcgf6 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Pcgf6
Locus ID	71041
Kit Components	GA208706G1, Pcgf6 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA208706G2, Pcgf6 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA208706G3, Pcgf6 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_027654, NR_133574, NR_153762, NM_001360632
Synonyms	4933407A11Rik; AI604840; MBLR; Rnf134
Summary	Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity.[UniProtKB/Swiss-Prot Function]

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