Mouse Osbpl3 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Osbpl3
Locus ID	71720
Kit Components	GA208909G1, Osbpl3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA208909G2, Osbpl3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA208909G3, Osbpl3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001163645, NM_001347213, NM_027881
Synonyms	1200014M06Rik; 6720421I08Rik; A530055M08; ORP-3; ORP3; OSBP3
Summary	Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes. Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With VAPA, may regulate ER morphology. Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion. Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3. Also binds 25-hydroxycholesterol and cholesterol.[UniProtKB/Swiss-Prot Function]

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