Mouse Lrwd1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Lrwd1
Locus ID	71735
Kit Components	GA208918G1, Lrwd1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA208918G2, Lrwd1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA208918G3, Lrwd1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_027891
Synonyms	1200011O22Rik; AU042569; AW548074; Orca
Summary	Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation (By similarity). Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability.[UniProtKB/Swiss-Prot Function]

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