Mouse Tdrd12 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Tdrd12
Locus ID	71981
Kit Components	GA209043G1, Tdrd12 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA209043G2, Tdrd12 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA209043G3, Tdrd12 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001082581, NM_028034, NM_001368387
Synonyms	2410004F06Rik; 2410070K17Rik; ECAT8; EG434165; G1-476-14; repro23
Summary	Probable ATP-binding RNA helicase required during spermatogenesis to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (PubMed:24067652). Involved in the secondary piRNAs metabolic process (PubMed:24067652). Acts via the PET complex, a multiprotein complex required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs (PubMed:26669262).[UniProtKB/Swiss-Prot Function]

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