Mouse Ddx42 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Ddx42
Locus ID	72047
Kit Components	GA209075G1, Ddx42 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA209075G2, Ddx42 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA209075G3, Ddx42 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_028074, NM_001361640, NM_001361642, NM_001361643, NM_001361644
Synonyms	1810047H21Rik; AW319508; AW556242; B430002H05Rik; RHELP; RNAHP; SF3b125
Summary	ATP-dependent RNA helicase. Binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. Unwinding is promoted in the presence of single-strand binding proteins. Mediates also RNA duplex formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands. Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the apoptosis-stimulating activity of TP53BP2. Relocalizes TP53BP2 to the cytoplasm (By similarity).[UniProtKB/Swiss-Prot Function]

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