Mouse Cnot2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Cnot2
Locus ID	72068
Kit Components	GA209084G1, Cnot2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA209084G2, Cnot2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA209084G3, Cnot2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001037846, NM_001037847, NM_001037848, NM_028082, NR_024327, NM_001359247, NM_001359248, NM_001359249, NM_001359251, NM_001359250, NM_001359252, NM_001359253, NM_001359563
Synonyms	2600016M12Rik; 2810470K03Rik; AA537049; AA959607; AW557563; C79650
Summary	Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of embryonic stem (ES) cell identity; prevents their differentiation towards extraembryonic trophectoderm lineages.[UniProtKB/Swiss-Prot Function]

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