Mouse Trim29 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Trim29
Locus ID	72169
Kit Components	GA209137G1, Trim29 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA209137G2, Trim29 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA209137G3, Trim29 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_023655
Synonyms	1110047J21Rik; 2810431N19Rik; 4732461M22Rik; AI119726
Summary	Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of proinflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of TMEM173/STING in a similar way, leading to its degradation.[UniProtKB/Swiss-Prot Function]

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