Mouse Tonsl activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Tonsl
Locus ID	72749
Kit Components	GA209332G1, Tonsl gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA209332G2, Tonsl gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA209332G3, Tonsl gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_183091
Synonyms	2810439M11Rik; Nfkbil2
Summary	Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork-associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA. Within the complex, may act as a scaffold (By similarity).[UniProtKB/Swiss-Prot Function]

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