Mouse Kremen2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Kremen2
Locus ID	73016
Kit Components	GA209389G1, Kremen2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA209389G2, Kremen2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA209389G3, Kremen2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_028416
Synonyms	2900054E04Rik; Krm2
Summary	Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6 (PubMed:12050670). Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation (PubMed:18505822).[UniProtKB/Swiss-Prot Function]

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