Mouse Glyr1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Glyr1
Locus ID	74022
Kit Components	GA209678G1, Glyr1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA209678G2, Glyr1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA209678G3, Glyr1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001079814, NM_028720, NM_001359747, NM_001359748
Synonyms	2810419J22Rik; 3930401K13Rik; AW545332; Npac
Summary	Putative oxidoreductase that is recruited on chromatin and promotes KDM1B demethylase activity. Recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3). Regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 and specifically regulating MAPK14 signaling. Indirectly promotes phosphorylation of MAPK14 and activation of ATF2. The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6.[UniProtKB/Swiss-Prot Function]

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