Mouse Nmnat3 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Nmnat3
Locus ID	74080
Kit Components	GA209707G1, Nmnat3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA209707G2, Nmnat3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA209707G3, Nmnat3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_144533, NM_001357445, NM_001357446, NM_001357449, NM_001357451, NM_001357452
Synonyms	4933408N02Rik; PNAT3
Summary	Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury.[UniProtKB/Swiss-Prot Function]

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